Tempus unveils a standalone tool for structuring clinical data at scale

technology, tech, IT, health IT, information technology

So why do some patients react to immuno-oncology drugs when others don’t?

It’s one of several million-dollar questions in medicine that confound companies, researchers, and clinicians alike. And also the really frustrating part? We all know where most of the solutions lie. They’re held in electronic health records (EHRs) and siloed by disparate health systems.

Chicago, Illinois-based Tempus is trying to extract that information at scale. The 2-year-old company lately started offering an operating-system, dubbed Tempus O, made to structure, cleanse, and annotate clinical data.

Tempus O is a a part of an finish-to-finish service which includes full DNA and RNA sequencing at its CAP/CLIA-certified labs. However, the organization found a lot of its clients wanted to pay attention to the information organization component, Chief executive officer Eric Lefkofsky stated, to harness the phenotypic, therapeutic, and outcome and response data.

“People wish to structure this data clinically simply because they think that getting that data in their fingertips will assist them have better choose to their sufferers,” Lefkofsky stated via phone. “And people wish to structure that data for research because, clearly, it’s vital to allow them to understand: Exist particular characteristics leading many people to possess outsized positive or outsized negative responses to the therapeutic?”

It’s harder of computer sounds.

Some medical records happen to be digitized recently, they’re not quite “user-friendly” sources. These were created for medical billing, in the end. Many of the important information is tangled up in free text — individuals hastily written progress notes.

Tempus O taps into some sophisticated workflow tools, including optical character recognition and natural language processing, which extract meaning out of this text. Individuals notes may then be compared and arranged inside a bigger dataset, together with insights from research databases, images, and scans. Lefkofsky stated the organization has additionally developed a group of abstractors that may by hand input data when needed and evaluate the finished work.

Obviously, all this is performed at scale, to power real insights.

“To provide you with some perspective with that, we predict to structure around 400,000-patients price of data within the next 12 several weeks,” Lefkofsky stated.

That’s almost one-quarter from the 1.seven million Americans likely to be identified as having cancer in 2017.

Unsurprisingly, there’s big interest in this kind of software.

In September, Tempus closed a $70 million Series C round co-brought by New Enterprise Associates (NEA) and Revolution Growth. That cash injection introduced the startup’s total funding to $130 million. (Lefkofsky, a serial entrepreneur, has additionally invested a lot of personal money).

It’s only some of the player hanging around. Palo Alto, California-based Syapse closed a $$ 30 million Series D round in November, for as many as $71 million elevated.

While Syapse also activly works to bring fragmented clinical, molecular, treatment, and health outcomes data together, it is centered on the program component. Instead of carry out the sequencing, it’s collaborations with assorted labs.

Inside a This summer interview with MedCity News, Lefkofsky stated a part of his company’s edge continues to be the opportunity to do all of it, to simplify the connection using the client.

Nevertheless the molecular information is generated, both Syapse and Tempus concurs the two data sources have to be examined together.

“As a business, we’re most thinking about the mixture of both clinical data and also the molecular data,” Lefkofsky stated. “When you will find the molecular data you may also answer the ultimate goal question, that is ‘why.’ How come these patients responding well? How come these patients not responding well? For cancers, that’s a molecular question frequently.”

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Ginger root.io transforms from mental health management tech for hospitals to doctor

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Previously few years, Ginger root.io has transformed itself from the mental health management technology business which used people’s smartphone behavior to recognize patterns and gather insights on their own mental health for hospitals to some doctor that gives use of licensed therapists through its application, according to an announcement from the organization now.

Ginger root.io offers the application through UnitedHealthcare, Optum and most 25 self-insured employers, the organization release stated.

“We think that a persons-to-human experience is important for mental and emotional health support. By integrating significant data and machine learning in to the process, we built the very first modern, nationwide behavior health system that is dependant on measurement-based care,” stated Karan Singh, Ginger root.io cofounder within the release.

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Ginger root.io Cofounder and Chief executive officer Dr. Anmol Madan told MobiHealthNews that the organization altered its approach because its model would take too lengthy for that medical industry to consider.

I was making lots of progress there we’d 40 different hospitals which were using our technology. However it only agreed to be a sluggish process so we felt that … by getting to deal with the clinical components and mixing it using the technology, we’re able to work directly with those who are having to pay for healthcare — i.e. the employers, the typical consumer, the plans — so we could provide the complete.Inches

Their revised approach involves an account balance between cognitive behavior therapy quite happy with information about how to higher deal with conditions for example depression and supplying video visits with licensed therapists and board-certified psychiatrists, who could prescribe medication with respect to the condition.

Karan also described that the organization requires a page from Lyft for the reason that it encourages patients to rate the caliber of these interactions as a means of improving its service.

Ginger root.io’s technology was initially produced for behavior health researchers in, but experienced multiple iterations to reply to a growing users list.

In 2015, Ginger root.io elevated $20 million from Kaiser Permanente Ventures, Khosla Ventures and True Ventures to deepen and expand its core mental health platform.

Although Ginger root.io has altered its model, there are a handful of firms that see the need for using smartphones like a vehicle for collecting data to evaluate emotion, cognition, and behavior.

Mindstrong describes this as digital phenotyping. Cofounder and president Thomas Insel labored as director from the National Institute of Mental Health for 13 years before joining Google’s healthcare arm Verily and subsequently, Mindstrong.

In June, Mindstrong raised $14 million inside a Series A round brought by Foresite Capital and ARCH Venture Partners. Optum Ventures, Berggruen Holdings and also the One Mind Brain Health Impact Fund also required part within the funding round to assist support product and also the development of Mindstrong’s clinical operations team.

HealthRhythms is comparable but different for the reason that it aggregates data from the wider selection of devices. Additionally to smartphones, additionally, it taps wearables and connected devices, examines data on exercise and usage, rates of speech and appears for patterns that could indicat changes in behavioral health.

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MedCity ENGAGE, October 23-24 in North Park, concentrates on the most recent strategies and innovations to boost patient engagement, care delivery and company wellness. Use code MCNTAG in order to save $50.

Health2047 spins out healthcare data discussing business

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Health2047 has spun out a technology company to talk about health data between patients, physicians, healthcare facilities, payers, pharma along with other healthcare enterprises, based on a news release.

Health2047 closed a $ten million Series A round for Health2047 Switch, however the spinout also received another $12 million, the discharge stated.

The move follows adding Celgene like a collaboration partner recently. The pharma company was introduced aboard by Health 2047 to assist build the bandwith business. Doug Given, Health2047 Chief executive officer, described at that time there was an interest in developing a method to move data better between pharmacies, patients, and physicians.

The offer reflects the driving pressure behind Health2047. The audience is associated with the Ama. It seeks to enhance the way digital health tools are developed and commercialize them through partnerships with established companies and startups.

Inside a phone interview with Given, he stated the funding could be utilized in part to improve staff. They of 14 would expand to 60-80 quickly the following 12 to 18 several weeks. The brand new hires is going to be mostly software engineers dealing with pilot customers and driving for scale.

Given stated the motivation behind the Switch is to produce a common mechanism to talk about data between greater than 100 major healthcare systems. To that particular finish, Switch works with every of Health2047’s stakeholders. The information transmission network includes Health Information Exchanges and let personal health records to become transmitted.

Adriaan Ligtenberg, a md with Health2047, will mind up Switch because the Chief executive officer. He formerly brought cardiovascular medical device monitoring business BMEYE BV, which Edwards Lifesciences acquired this year. Charles Aunger assists as CTO. He formerly offered as senior executive director from it at Stanford Healthcare.

“We is going to be at alpha and beta stage and also have a minimally viable product throughout the the coming year. Then we are moving beta users to general availability” in 2019, Given stated.

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MedCity ENGAGE, October 23-24 in North Park, concentrates on the most recent strategies and innovations to boost patient engagement, care delivery and company wellness. Use code MCNTAG in order to save $50.

Celebrating and highlighting digital health innovation within the Midwest

On Thursday, MedCity News, together with Minnesota-based Medical Alley, will host the very first satellite event in our annual INVEST conference (locked in Chicago) within the Twin Metropolitan areas.

We’re concentrating on digital health but in Minnesota? Well, the condition is a notable healthcare hub for many years. The condition hosts heavyweights like Medtronic (yes, the organization searched for a tax haven in Dublin, however the executive offices continue to be located in the Land of 10,000 Ponds), UnitedHealth Group and also the Mayo Clinic.

What many may not be conscious of is the fact that in 2011 Minnesota was the place to find 1 of 2 pilot projects the Office of National Coordinator was running included in the Direct Project initiative. Per its website, the Direct Project “develops specifications for any secure, scalable, standards-based method to establish universal health addressing and transport for participants (including providers, laboratories, hospitals, pharmacies, and patients) to transmit encrypted health information straight to cryptographically validated recipients on the internet.Inches

Quite simply, this public-private partnership is searching to build up web-based tools for transmitting patient data via electronic health information exchange (HIE). As well as in The month of january 2011, the Hennepin County Clinic (HCMC), an amount 1 trauma center in Minneapolis, started delivering immunization records towards the Minnesota Department of Health (MDH) while using Direct framework.

HCMC’s perspective on digital health is going to be reflected at our conference Thursday when Kim Wiese, v . p . of Portfolio Management and Growth, will participate on the panel discussing what’s stopping the adoption of digital health. We’ll also listen to Kyle Rolfing, who’s creating a new kind data-driven and wealthy-in-consumer experience insurance provider with Vibrant Health, also located in Minnesota.

We’ll also host Pitch Perfect, a startup contest where 10 startups will attempt to thrill investors who’ll evaluate these questions Shark Tank-like style. After applications came flooding in, reviewers selected the ultimate 10, many of which call MN home, however a couple of originate from Kentucky, Illinois you will find, even Colorado.

FDA’s Pre-cert digital health innovation pilot contained just nine companies and here’s who they really are where they’re based.

  • Apple, Cupertino, California
  • Fitbit, Bay Area, California
  • Manley & Manley, New Brunswick, Nj
  • Pear Therapeutics, Boston, Massachusetts
  • Phosphorus, New You are able to, New You are able to
  • Roche, Basel, Europe
  • Samsung, Seoul, Columbia
  • Tidepool, Palo Alto, California
  • Verily, Mountain View, California

Food and drug administration find the companies it felt it might gain knowledge from the most, stated Bakul Patel, associate director for digital health within the FDA’s Center for Devices and Radiological Health, but it’s as though the wide swath of the nation was simply overlooked.

Celebrating and highlighting digital health innovation everywhere is essential to ensure that novel and worthy startups obtain the attention of investors, both traditional vc’s and proper investors to build up their visions. Ultimately, the aim would be to develop products that will help patients everywhere.

We’re beginning with highlighting digital health innovation in Minnesota. I think you’ll will come along there.

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Report: Sean Parker and Peter Thiel back cancer immunotherapy startup 3T Biosciences

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Twelve months after establishing a $250 million institute dedicated to cancer immunotherapy, Sean Parker has backed 3T Biosciences alongside fellow millionaire investor Peter Thiel. Both were a part of a $12 million + funding round for that stealth immunotherapy business, based on a CNBC report. It is among several biopharma companies taking a cutting-edge method of cancer treatment.

Asset Management Ventures’ principal Luke Lee is heading up 3T, based on CNBC. Christopher Garcia, who runs a biology lab at Stanford College, is one kind of several academics dealing with the stealth startup.

The Parker Institute spans six centers using more than 63 labs and various researchers and industry and nonprofit partners. The Institute also pools and shares its sources.

You will find 240 cancer immunotherapies under development, according to the trade group PhRMA.

Novartis guaranteed Food and drug administration approval because of its Chimeric Antigen Receptor-engineered T-cell therapy for relapsed and refractory (r/r) B-cell acute lymphoblastic leukemia this season, however, many companies see possibilities and investor curiosity about evolving their very own immunotherapy treatments.

Recently, RepImmune elevated $55 million inside a Series B round for immunotherapy targeting multiple solid tumor types. Its treatment, RP1, is supposed to activate innate and adaptive immune responses. Another biotech, Gritstone Oncology, that is developing neoantigen-targeted immunotherapies for lung and gastric cancer, elevated greater than $92 million and in a Series B round. It’s likely to start numerous studies the coming year. RepImmune is applying the funding for proof-of-concept studies.

Merck inked a $200 million licensing agreement with Moderna Therapeutics this past year. The aim would be to identify unique mutations inside a given cancer, as a first step for cancer vaccine development for a specific immune response.

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MedCity ENGAGE, October 23-24 in North Park, concentrates on the most recent strategies and innovations to boost patient engagement, care delivery and company wellness. Use code MCNTAG in order to save $50.

Beyond Gaming: How Osso VR has already been Transforming Surgical Training

Inside a nondescript business building in downtown Palo Alto, I enter a celebration room using the furnishings of an average Plastic Valley tech company. All of a sudden, my view changes, and i’m transported to the inside of the brightly lit operating room, myself fully gowned and looking lower in the uncovered knee of the anesthetized patient. I turn my mind right, get an memory foam insertion handle, and gradually step toward the individual.

So begins my ending up in our very own Medgadget editor, Dr. Justin Barad, who’s co-founder and Chief executive officer of Osso VR, a business that’s trying to modernize surgical training through using virtual reality (VR).

But what about surgical training that needs technological disruption?

Based on Barad, the normal training process for surgeons (a minimum of the memory foam niche) largely includes low-tech instruction manuals and videos, and frequently involves visiting one-day surgical courses. On occasion, there can be just one brief training procedure on the cadaver. It is often many several weeks later that the surgeon is thrown into the operating room to do the recently learned technique on real patients without getting had any real practice. It’s no question that residents can become so uneasy throughout their first live surgeries, and patients consequently can be averse to being operated on in teaching hospitals or given new surgical techniques.

With Osso VR, orthopedic surgeons can’t only freely look and move about their atmosphere having a VR headset, however the hands controllers permit them to hold and manipulate tools and devices within the right sequence and “operate” on the patient’s leg with accurate and precise movements. Even though it could initially seem similar to a far more serious form of choices Simulator 2013 game we authored about in 2013, Osso VR helps make the experience as accurate as you possibly can and grades your speed and agility according to time, precision, along with other metrics that surgeons are usually evaluated on.

One benefit of the is the fact that memory foam surgeons can train for procedures by themselves time before operating on real patients. Osso VR can also be provided to first-year medical students (or paradise forbid, armchair surgeons like this writer) to jumpstart their training.

Similar to VR-based encounters, haptic feedback was restricted to soft taps and vibrations when drilling and hammering. I requested Barad if too little realistic tactile feedback was ever an item of concern. He replied that, surprisingly, the VR experience is really immersive the brain tends to create its very own haptic feedback if this thinks the hands should be touching or grasping something, and also the user doesn’t even understand it. He even shared that the very first time he performed with Intuitive Surgical‘s da Vinci Surgical Robot, he remarked how great the tactile feedback was, despite the fact that there wasn’t any!

I additionally requested Barad a little about the caliber of the graphics. While Osso VR is made around the popular Unity game engine, you most likely wouldn’t think about the graphics to become super photorealistic. Barad shared that the objective of Osso VR isn’t to coach with minute precision it’s to obtain users confident with the succession of occasions inside a surgical procedure and to coach them ways to use the different tools and devices. As users is constantly on the train using the software, these steps eventually be muscle memory, letting them focus more about precision and technique when the time comes to function on live patients. Barad also surmised that excessively-realistic graphics could have unintended negative consequences with the “uncanny valley” phenomenon, so Osso VR’s were intentionally stylized.

While Osso VR is just a little more than a year old, they’ve been hugely effective as recently. They lately elevated $two million in funding and won awards from MedTech Innovator and also the U.S. Department of your practice. Most proudly, Barad shared, was that the recent UCLA study demonstrated that several first-year medical students who trained to carry out a tibial nail placement procedure using Osso VR outperformed a control number of newbie medical students who performed the process without training, according to evaluations from the blinded observer. Their scores were similar to the level of skill of the second or 3rd year surgical resident!

And Osso VR is only getting began. Barad shared that additionally to medical schools, Osso VR is already working with several major memory foam medical device manufacturers to build up practicing using and implanting their devices.

I’ve always thought virtual reality to be yet another novelty technology with limited utility. But after demoing Osso VR’s realistic and immersive experience to be the mind and hands of the memory foam surgeon, I’m starting to think there can be a spot for VR outdoors from the gaming and technology industry. A short escape in to the virtual world certainly isn’t a poor factor if it is helping to improve real lives.

The Medgadget team is honored that Justin is a valuable a part of the family for more than ten years and are excited to determine what surgical training programs he’s prepared to disrupt!

More details: Osso VR…

Tim Prepare: Healthcare is a huge position for Apple’s future

Apple Chief executive officer Tim Prepare

As Apple prepares to drag the wraps from the latest type of its iPhone tomorrow, Chief executive officer Tim Prepare shared his excitement about’s Apple’s healthcare applications and also the role it’ll participate in the way forward for the organization within an interview with Fortune.

Although Apple has indicated its curiosity about healthcare before, Prepare noted that the organization is especially thinking about medical activity.

We’re very interested in this region. And, yes, it’s a business chance. If your perception, medical health activity may be the largest or second-largest element of the economy, based on which country on the planet you’re coping with. Also it hasn’t been built in ways in which the focus in the device level is making great products from the pure perspective. The main focus continues to be on making items that could possibly get reimbursed with the insurance providers, through Medicare, or through State medicaid programs. And thus somewhat we bring an entirely fresh view into this and say, ‘Forget all that. What’s going to help people?’

Prepare came focus on Apple’s heart monitoring technology on its smartwatch heartbeat readings, that your Stanford College study captured discovered to be better than seven other wearable devices. Like Fitbit executives, Prepare noted that it is device alerted users to some potential heart problem and could share heartbeat data with doctors. He stated, “a not-minor number have discovered when they hadn’t enter into the physician they’d have left.Inches

Also, he recommended that ResearchKit, while a terrific way to modernize and let large studies, does not have a company model which was one thing the company did for that betterment of society. Although that sounds noble it isn’t entirely convincing. It’s entirely possible that the statistics generated from these studies will factor into longer-term possibilities. In almost any situation, the organization isn’t disclosing its big plans yet.

Apple’s moves in healthcare have significant ramifications from health application developers to medical device companies for example DexCom to patients and clinicians. When Apple added technology to enhance connectivity for that smartwatch with hardware devices for example continuous glucose meters, it boosted DexCom’s share cost.

As Cook noted within the interview, the organization is simply scratching the top of their abilities. It will likely be exciting to determine what comes next in Apple’s healthcare toolkit.

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MedCity ENGAGE, October 23-24 in North Park, concentrates on the most recent strategies and innovations to boost patient engagement, care delivery and company wellness. Use code MCNTAG in order to save $50.

Three methods to enhancing medical trial recruitment

Considering that numerous studies represent the greatest discomfort point for drug development in the painstakingly slow recruitment process and the necessity to discover the most appropriate candidates, it’s interesting to determine how information mill dealing with the task in their own individual unique way. Now, three different companies made news now regarding the way they were attempting to enhance the recruitment experience for patients as well as for pharma companies.

The team at Facebook, a social networking that has formerly hinted in a variety of ways in which it thinking about being more involved with healthcare, located a breakfast for drug marketers to describe a brand new medical trial strategy thiis week. It spoken about how exactly drug companies may use its vast network to recognize and discover medical trial candidates and remain around the right side from the law, based on a CNBC article.

Organizations like the Michael J Fox Foundation have had the ability to cut costs making recruitment more effective by advertising for numerous studies online. This past year MJFF found they could save a boatload on the price of ads in contrast to traditional advertising strategies and also the organization could boost recruitment substantially.

Now, Antidote Technologies elevated $11 million inside a Series A round because of its medical trial matching business brought by Merck Global Health Innovation Fund with participation from existing investors Smedvig Capital and Octopus Ventures.

Antidote includes a medical trial search tool in excess of 180 patient communities and health portals within the U.S. and United kingdom. Users complete a questionnaire to allow them to find out the best numerous studies nearby. A few of the company’s medical trial tools are highlighted on its website. For instance, an “Antidote Bridge” gives procedure descriptions, the number of overnight stays, placebo use, and financial compensation details to patients for every trial. Antidote API helps you to screen patients for many numerous studies at the same time. The fundraise can help the company harness data from EHRs because of its trial matching platform towards precision medicine.

The clinical trial matching service contends that 80 % of numerous studies have to shut lower prematurely simply because they don’t recruit enough participants. The concept is to really make it simpler for patients to locate relevant trials, in addition to nurses and doctors. Still, physicians and nurses stated they often times decline to touch on patients to numerous studies due to the lack of ability to gain access to information or inadequate details are available about numerous studies, based on a January report from Tufts Center for study regarding Drug Development.

VitalTrax now launched Wing, an item made to simplify the job to find trials having a user friendly interface. Users can look for trials by hitting fundamental criteria for example gender, location, and condition, but they may also choose the status from the study, the kind of trial, and also the phase from the medical trial. Design and also the choices are less confusing than, say, searching of numerous studies.gov.

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